Completed

All Genders
ID00001363

Functional Brain Mapping of Planning Activities With [015] Water PET Blood Flow Technique

Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2008-03-04

230

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow. This study will attempt to determine the areas of the brain activated by planning processes and decision making. Researchers will ask patients to participate in tests and games (chess) that will stimulate the areas of the brain involved with decision making and planning while undergoing the water PET blood flow technique.

CONDITIONS

Official Title

PET Scan to Map the Areas of the Brain Involved in Planning

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

Normal Controls:

Males and female subjects from two age ranges: 18-30 and 50-65 years of age.

Individuals with a history of neurological or psychiatric disorder will not be included nor will individuals currently taking psychoactive medication.

Patients:

Patients with outstanding problems in planning.

Patients must have a diagnosed CNS disorder with lesion localization verified by MRI scanning available from the referring physician or completed at the NIH Clinical Center.

Patients with unilateral or bilateral lesions that meet the behavioral criteria for selection (planning disorder).

Patients will be medication free (or taking medication with no known central nervous system effects) and be able to understand instructions and task demands.

Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

Trial Site Locations

Total: 1 location

1

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, United States, 20892

Status Unknown

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How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial