Status:
COMPLETED
Role of T-Cells in Asthma
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Asthma
Eligibility:
All Genders
18-65 years
Brief Summary
This study will examine the movement of T cells (a type of white blood cell) from the blood to the lungs in patients with asthma after exposure to an allergen, such as cat dander or pollen. Asthma is ...
Detailed Description
In the last 10 years it has become generally accepted that asthma is an inflammatory disease of the airways. T lymphocytes play a key role in regulating this inflammatory response, through the elabora...
Eligibility Criteria
- INCLUSION CRITERIA - BLOOD DRAW/ASTHMA:
Age 18-65.
Asthma of greater than one year duration.
Willingness to adhere to effective contraception in women of child bearing age.
Negative HIV test.
EXCLUSION CRITERIA - BLOOD DRAW/ASTHMA:
For blood draws of greater than 100 ml, a hemoglobin of less than 12.5 g/dl. For blood draws of 100 ml or less, performed less frequently than every 56 days, a hemoglobin of less than 10.0 g/dl.
Current pregnancy.
Medical history suggesting lung diseases other than asthma.
History of immunodeficiency or HIV infection.
INCLUSION CRITERIA - BLOOD DRAW/NORMAL CONTROL:
Age 18-65.
Willingness to adhere to effective contraception in women of child bearing age.
Negative HIV test.
EXCLUSION CRITERIA - BLOOD DRAW/NORMAL CONTROL:
For blood draws of greater than 100 ml, a hemoglobin of less than 12.5 g/dl. For blood draws of 100 ml or less, performed less frequently than every 56 days, a hemoglobin of less than 10.0 g/dl.
Current pregnancy.
Positive skin test to one or more allergens in the battery tested.
History of asthma or other allergic diseases, such as hay fever.
Medical history suggesting lung diseases other than asthma.
History of immunodeficiency or HIV infection.
INCLUSION CRITERIA - EXHALED BREATH CONDENSATE/ASTHMA:
Age 18-65.
Asthma as diagnosed by a physician or use of medications consistent with the treatment of asthma.
Subjects must have a doctor outside NIH and they will provide routine and emergency care.
EXCLUSION CRITERIA - EXHALED BREATH CONDENSATE/ASTHMA:
History of immunodeficiency or HIV infection.
History of allergy to latex.
INCLUSION CRITERIA - EXHALED BREATH CONDENSATE/HEALTHY CONTROL:
Age 18 - 65.
EXCLUSION CRITERIA - EXHALED BREATH CONDENSATE/HEALTHY CONTROL:
History of asthma or other allergic diseases, such as allergic rhinitis.
Medical history suggesting lung diseases other than asthma.
History of allergy to latex.
History of immunodeficiency or HIV infection.
Key Trial Info
Start Date :
September 14 1994
Trial Type :
OBSERVATIONAL
End Date :
October 1 1995
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00001408
Start Date
September 14 1994
End Date
October 1 1995
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892