Status:
COMPLETED
Hormonal Effects on the Uterus and Endometrium
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Pregnancy
Eligibility:
FEMALE
18-43 years
Brief Summary
Endometrium is the lining of the uterus. It is where the fertilized egg normally implants during pregnancy. This study was designed to better understand the way(s) that female sex hormones (estrogen ...
Detailed Description
Estrogen and progesterone induce characteristic and predictable morphological changes in the endometrium that are required for successful implantation and pregnancy. The mechanism(s) by which estrogen...
Eligibility Criteria
- INCLUSION CRITERIA:
Healthy volunteers will be in excellent health.
Only women with regular menstrual cycles (every 26-35 days) using mechanical (condoms, diaphragm) or sterilization methods of contraception will be included.
Only women with a negative pregnancy test, normal physical examination and laboratory results, and a luteal phase progesterone value of greater than 4 ng/mL will be entered into this study.
Women with endometriosis will be recruited from those with histologically-proven endometriosis. Except for this diagnosis they will meet criteria for healthy volunteers as stated above.
Women may participate in the study on more than one occasion, but biopsies may not be performed in a "baseline" cycle.
Key Trial Info
Start Date :
April 21 1995
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 27 2015
Estimated Enrollment :
129 Patients enrolled
Trial Details
Trial ID
NCT00001454
Start Date
April 21 1995
End Date
July 27 2015
Last Update
December 16 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892