Attentional deficits in long-term survivors of childhood acute lymphoblastic leukemia (ALL).
P Brouwers, R Riccardi, D Poplack...
https://pubmed.ncbi.nlm.nih.gov/6590573Completed
All Genders
ID00001497
Assessment of Attentional Functioning in Children With HIV-1 Infection
Led by National Cancer Institute (NCI) · Updated on 2008-03-04
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Children with symptomatic HIV-1 (Human Immunodeficiency Virus) infection are at increased risk for developing severely disabling neurological and neuropsychological deficits. HIV-1 related CNS (Central Nervous System) disease is a clinical syndrome, manifested by varying and sometimes discordant degrees of cognitive, motor and behavioral impairment. A continuum of clinical presentations attributed to the effects of HIV-1 infection on the CNS, ranging from apparently normal development, decreases in the rate of new learning to the loss of acquired skills have been observed. Two domains of psychological functioning appear most susceptible to the effects of HIV infection on the central nervous system in children: expressive behavior and attentional processes (Brouwers, et al, 1994). Attention deficits have been documented as a relative weakness on the "freedom from distractibility" subclass of IQ tests (Brouwers et al, 1989) and on behavior assessment (Moss et al, 1994). Attention, however, has many subcomponents such as focused attention, divided attention, vigilance, etc. Direct assessment of attentional functioning using reaction time has not yet been conducted and questions whether attentional components are differentially affected by the virus have not been addressed. The proposed study would assess different components of attentional functioning in children with HIV-1 disease. A quantitative and systematic method is developed that could complement the existing standardized instruments used for measuring attention and neurocognitive function in this population. Simple alerted visual reaction time will be measured with varying preparatory intervals, a two-choice reaction time in a go/no-go paradigm will be administered, and a continuous performance, divided reaction time test and an object decision task will be given. Performance on these measures will also be related to measures of brain structure and stage of HIV-1 disease.
CONDITIONS
Official Title
Assessment of Attentional Functioning in Children With HIV-1 Infection
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
Children and adolescents with HIV infection ages 5-18.
Have to be on another treatment protocol at the Division of Clinical Sciences, NCI.
No children with non-HIV associated CNS compromise, such as for example resulting from head trauma, or genetic factors.
No children with uncorrectable (20/20) vision.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Cancer Institute (NCI)
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Correlation between computed tomographic brain scan abnormalities and neuropsychological function in children with symptomatic human immunodeficiency virus disease.
P Brouwers, C DeCarli, L Civitello...
https://pubmed.ncbi.nlm.nih.gov/7826274The prevalence of computed tomographic abnormalities of the cerebrum in 100 consecutive children symptomatic with the human immune deficiency virus.
C DeCarli, L A Civitello, P Brouwers...
https://pubmed.ncbi.nlm.nih.gov/8338344