A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
M Yanagisawa, H Kurihara, S Kimura...
https://pubmed.ncbi.nlm.nih.gov/2451132Completed
All Genders
Healthy Volunteers
ID00001527
Role of Endothelin in the Regulation of Vascular Tone in Patients With Essential Hypertension
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2008-03-04
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Endothelin-1 (ET-1) is a powerful vasoconstricting peptide produced predominantly by vascular endothelial cells, that exerts its effect through the interaction with specific receptors, ETA and ETB, on the underlying smooth muscle cells. Previous studies in normal subjects have demonstrated an increase in forearm blood flow after ET-1 antagonism, suggesting a physiologic role of ET-1 in the regulation of basal vascular tone. However, whether ET-1-mediated tone is increased in hypertensive patients is unknown. The main purpose of this study will be to compare the forearm vascular responses to local infusion of ET-1 receptor antagonists between normotensive and hypertensive subjects in order to assess whether ET-1-mediated basal tone is increased in patients with hypertension. In addition, we propose to study the vascular responses to local ET-1 infusion to determine whether vascular smooth muscle sensitivity to this peptide is increased in hypertensive vessels. We will use both an ETA receptor antagonist, BQ-123, and an ETB receptor antagonist, BQ-788, in order to evaluate the relative contribution of the two receptor subtypes to the regulation of vascular tone. All drugs will be infused into the brachial artery and the responses of the forearm vasculature will be measured by means of strain gauge plethysmography. Because of the relative long-lasting effect of most of the substances to be infused, the study will be performed on two separate occasions.
CONDITIONS
Official Title
Role of Endothelin in the Regulation of Vascular Tone in Patients With Essential Hypertension
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
Between 40-65 years old.
Normal Volunteers who are not taking medications. Have no medical problems. Cholesterol below 200 mg/dl. No contraceptives.
Hypertensive Patients with blood pressure greater than 145/90 off medications. Serum cholesterol less than 200 mg/dl. No other medical problems.
High cholesterol patients with cholesterol level greater than 250 mg/dl. No other medical problems.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.
G M Rubanyi, M A Polokoff
https://pubmed.ncbi.nlm.nih.gov/7831383Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor.
T Sakurai, M Yanagisawa, Y Takuwa...
https://pubmed.ncbi.nlm.nih.gov/2175397