Completed

All Genders
Healthy Volunteers
ID00001528

Post-Stress Left Ventricular Contractile Dysfunction: Does It Represent Persistent Myocardial Ischemia or Stunning?

Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2008-03-04

80

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart. The lowered blood supply to the heart muscle may not cause symptoms immediately. However, as the heart pumps faster and harder the blood supply demand is increased. If blood flow is unable supply enough oxygen and nutrition to heart muscle patients can experience symptoms of chest pain and shortness of breath. Even after the heart slows down and demand for oxygen and nutrition is reduced, patients can still experience pain and abnormal heart function. The purpose of this study is to determine the changes in blood flow and the beating function of the heart during periods of increased demands (such as exercise) and shortly after stopping exercise. Blood flow to the heart will be measured by positron emission tomography (PET scan). The PET scan is a test where a small amount of radioactive water is injected into the bloodstream and pictures of the heart are taken by the special camera. This procedure allows researchers to measure blood flow to heart muscle. In order to measure nutrition (metabolism) of the heart muscle, researchers will use a radioactive substance similar to sugar (Fluorodeoxyglucose). Results of this study may provide important information about the activity and function of heart muscle after exercise in patients suffering from coronary artery disease.

CONDITIONS

Official Title

Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease

Who Can Participate

All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

Adult patients with greater than 50% stenosis in at least one major coronary artery.

No significant valvular heart disease.

No congenital heart disease.

No myocardial disease unrelated to co-existing coronary artery disease.

No severe angina where withdrawal of therapy would be dangerous.

No recent unstable angina or myocardial infarction (less than 1 month).

Not pregnant or breast feeding.

No history of ventricular tachycardia or malignant arrhythmias.

No history of active bronchospastic disease.

Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

Trial Site Locations

Total: 1 location

1

National Heart, Lung and Blood Institute (NHLBI)

Bethesda, Maryland, United States, 20892

Status Unknown

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How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial