Status:
COMPLETED
Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Inflammation
Vasculitis
Eligibility:
All Genders
Brief Summary
This study will collect fluid and tissue samples from the bronchi (air passages to the lungs) of patients with Wegener's granulomatosis for laboratory examination. Wegener's granulomatosis is a type o...
Detailed Description
Wegener's granulomatosis is a systemic vasculitis in which parenchymal and/or endobronchial inflammation frequently occur. The purpose of this investigation is to analyze bronchial and bronchoalveolar...
Eligibility Criteria
INCLUSION CRITERIA:
Diagnosis of Wegener's granulomatosis based on clinical and histological characteristics.
Age between 18-75 years.
Bronchoscopy is required as part of their standard medical care.
FEV1 is greater than 55 percent of FVC.
O2 saturation is greater than 90 percent.
EXCLUSION CRITERIA:
FEV1 is less than 55% of FVC.
O2 saturation is less than 90%.
Abnormal PT, PTT, or platelet count less than 50.
History of adverse reaction to lidocaine or other local anesthetics.
Pregnancy.
Key Trial Info
Start Date :
April 1 1996
Trial Type :
OBSERVATIONAL
End Date :
January 1 2003
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00001541
Start Date
April 1 1996
End Date
January 1 2003
Last Update
March 4 2008
Active Locations (1)
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1
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, Maryland, United States, 20892