Dynamic mutations hit double figures.
P J Willems
https://pubmed.ncbi.nlm.nih.gov/7874160Completed
All Genders
ID00001544
Genetic Aspects of Neurologic and Psychiatric Disorders
Led by National Institute of Mental Health (NIMH) · Updated on 2008-03-04
1227
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to improve the understanding of the genetic causes of specific neurologic and psychiatric disorders. The study will focus on conditions of mental retardation, childhood onset schizophrenia, attention deficit hyperactivity disorder (ADHD), atypical psychosis of childhood, and bipolar affective disorder. The study addresses the belief that there may be several genes contributing to the illness. Researchers intend to use several molecular genetic techniques in order to identify the areas of chromosomes containing genes responsible for the development of these disorders. Patients will be selected to participate in this study based on an early age of onset of their condition as well as the severity of the illness and the frequency of the illness among family members. Researchers will collect DNA samples from patients as well as affected and unaffected family members of each patient. The DNA samples collected will be analyzed for a variety of genetic abnormalities including; triplet repeat expansions, chromosome rearrangements, and polymorphisms.
CONDITIONS
Official Title
Genetic Aspects of Neurologic and Psychiatric Disorders
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
INCLUSION CRITERIA:
Individuals with selected psychiatric and neurologic disorders, including childhood onset schizophrenia, atypical psychosis, mental retardation, bipolar affective disorder, and ADHD.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Institute of Mental Health (NIMH)
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA).
R Koide, T Ikeuchi, O Onodera...
https://pubmed.ncbi.nlm.nih.gov/8136840Direct sequencing of trinucleotide repeats from cosmid genomic DNA template.
R A Philibert, G A Hawkins, P Damschroder-Williams...
https://pubmed.ncbi.nlm.nih.gov/7762809