A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder.
Jens R Wendland, Pablo R Moya, Kiara R Timpano...
https://pubmed.ncbi.nlm.nih.gov/19349310Completed
Age: 18Years +
All Genders
ID00001548
Genetics of Obsessive-Compulsive Disorder: A Collaborative Study
Led by National Institute of Mental Health (NIMH) · Updated on 2017-10-06
1067
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition develops and ultimately improve treatment for people with OCD. OCD is a severe, familial condition that affects approximately 2% of the population. The way OCD is inherited is not clearly understood, but researchers believe it is complex and involves multiple genes. This study will detect and localize genes that increase or decrease susceptibility to OCD. The data collected from this study will be combined with data from other research studies to determine gene linkage and association.
CONDITIONS
Official Title
Genetics of Obsessive-Compulsive Disorder
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- INCLUSION CRITERIA:
Must have a diagnosis of obsessive-compulsive disorder, or be a family member (usually a parent or sibling) of someone with obsessive-compulsive disorder.
Certain disorders are considered part of OCD "spectrum" disorders and often include family members with OCD. These include Tourette's Syndrome, other individuals with tics, and Trichotillomania (severe hair pulling), and other forms of repetitive behaviors.
Persons with primary behavioral difficulties who do not fit with the current definitions of "OCD and OCD spectrum disorders" may not be eligible. These include compulsive shopping, gambling, or compulsive sexual behaviors.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Multiple rare SAPAP3 missense variants in trichotillomania and OCD.
S Züchner, J R Wendland, A E Ashley-Koch...
https://pubmed.ncbi.nlm.nih.gov/19096451A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder.
Jens R Wendland, Pablo R Moya, Matthew R Kruse...
https://pubmed.ncbi.nlm.nih.gov/18055562