Status:
COMPLETED
Comparison of Asymptomatic Carotid Atherosclerosis Between Frequent and Infrequent Blood Donors
Lead Sponsor:
National Institutes of Health Clinical Center (CC)
Conditions:
Carotid Atherosclerosis
Myocardial Infarction
Eligibility:
All Genders
Brief Summary
Iron has been proposed to contribute to atherogenesis in humans by facilitating the oxidation of lipoproteins. This observational study will evaluate the association between frequency of blood donatio...
Detailed Description
Iron has been proposed to contribute to atherogenesis in humans by facilitating the oxidation of lipoproteins. This observational study will evaluate the association between frequency of blood donatio...
Eligibility Criteria
INCLUSION CRITERIA:
Age greater than or equal to 40 years for males and greater than or equal to 50 years for females.
Standard eligibility criteria for blood donation, per guidelines established by the Food and Drug Administration and the American Association of Blood Banks.
Ability to provide consent after full information is provided.
EXCLUSION CRITERIA:
Pregnancy or lactation.
Patients with clinically significant dementia or psychiatric disturbances, including alcohol and substance abuse.
Presence of the following American Heart Association cardiovascular risks: diabetes mellitus, hypertension (systolic greater than 140 mmHg, diastolic greater than 90 mmHg), smoking (greater than 10 cigarettes/day), high density lipoprotein cholesterol less than 35 mg/dL, hyperlipidemia (total cholesterol greater than 240 mg/dL), family history of premature coronary heart disease.
Anticoagulant, thrombolytic, hemorrheologic and/or antiplatelet agents (within the last 10 days).
Any other condition or therapy which in the opinion of the investigators may pose a risk to the patient or confound the results of the study.
Key Trial Info
Start Date :
April 1 1997
Trial Type :
OBSERVATIONAL
End Date :
May 1 2002
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00001589
Start Date
April 1 1997
End Date
May 1 2002
Last Update
March 4 2008
Active Locations (1)
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1
Warren G. Magnuson Clinical Center (CC)
Bethesda, Maryland, United States, 20892