Status:
COMPLETED
Genetic Linkage Studies of Stuttering
Lead Sponsor:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Stuttering
Eligibility:
All Genders
6+ years
Brief Summary
Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unneces...
Detailed Description
A primary goal of this study is to ascertain regions of the human genome which show genetic linkage to stuttering. Genetic linkage will be determined by first obtaining genomic DNA from both affected ...
Eligibility Criteria
- INCLUSION CRITERIA:
- Individuals age 8 and older.
- Individuals age 6-8 with a family history of persistent stuttering
- Have stuttering that persists for a period of 6 months or more or are a family member of that person
- For the Phase 2 imaging studies, we will be enrolling up to 25 healthy volunteers to be controls
EXCLUSION CRITERIA:
- Stuttering only as a young child (before age 5) with no other family members who stutter
- Inability to provide informed consent or have a parent/guardian to provide consent
- Development of stuttering following trauma to the central nervous system.
- Chronic medical conditions that prevent informed consent or clear evaluation of stuttering, including stroke, dementia, and degenerative neurological disease.
- Inability to travel to the NIH Clinical Center for Phase 2
Key Trial Info
Start Date :
July 22 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 24 2019
Estimated Enrollment :
3044 Patients enrolled
Trial Details
Trial ID
NCT00001604
Start Date
July 22 2003
End Date
June 24 2019
Last Update
November 18 2024
Active Locations (3)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
2
National Rehabilitation Center for Persons with Disabilities Hospital
Saitama, Japan
3
NCEMB - University of Punjab
Lahore, Pakistan