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Status:

COMPLETED

The Role of Bacteria and Genetic Variations in Cystic Fibrosis

Lead Sponsor:

National Heart, Lung, and Blood Institute (NHLBI)

Conditions:

Psuedomas Infection

Cystic Fibrosis

Eligibility:

All Genders

9-80 years

Brief Summary

This study will examine 1) the role of hereditary factors in cystic fibrosis; i.e., the relationship of the disease to specific gene variations, and 2) the role of bacterial products involved in lung ...

Detailed Description

Individuals with cystic fibrosis (CF) are susceptible to chronic bacterial colonization by Pseudomonas aeruginosa, which results in deterioration of lung function and, eventually, death. In this study...

Eligibility Criteria

Inclusion

  • INCLUSION CRITERIA:
  • Patients with cystic fibrosis who have a defined mutation in CFTR (e.g., any of the known variants of the CFTR gene, such as the delta F508 allele) born in the state of Wisconsin since 1985 or otherwise followed by the cystic fibrosis centers at the Medical College of Wisconsin or University of Wisconsin-Madison.
  • Patients will have been tested or will be tested for the CFTR gene under another protocol (96-H-0100).
  • Patients may be colonized with P. aeruginosa or other organisms (e.g., Burkholderia cepacia).
  • The age range of NIH participants in this study is from 9 to 80 years old.
  • EXCLUSION CRITERIA:
  • There are no exclusion criteria.

Exclusion

    Key Trial Info

    Start Date :

    June 20 2001

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ACTUAL

    End Date :

    July 10 2018

    Estimated Enrollment :

    76 Patients enrolled

    Trial Details

    Trial ID

    NCT00043225

    Start Date

    June 20 2001

    End Date

    July 10 2018

    Last Update

    June 29 2021

    Active Locations (4)

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    Page 1 of 1 (4 locations)

    1

    National Institutes of Health Clinical Center, 9000 Rockville Pike

    Bethesda, Maryland, United States, 20892

    2

    University of Washington

    Seattle, Washington, United States, 98195

    3

    University of Wisconsin

    Madison, Wisconsin, United States, 53792

    4

    Medical College of Wisconsin

    Milwaukee, Wisconsin, United States