Status:
COMPLETED
Familial Intracranial Aneurysm Study II
Lead Sponsor:
University of Cincinnati
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Intracranial Aneurysm
Subarachnoid Hemorrhage
Eligibility:
All Genders
13+ years
Brief Summary
The purposes of this study are to identify possible genes that may increase the risk of aneurysm development in the brain, and to determine the effect of environmental factors such as cigarette smokin...
Detailed Description
Intracranial aneurysms are "blisters" which form within the arteries at the base of the brain. A rupture of an aneurysm may lead to subarachnoid hemorrhage (SAH). The mortality rates of patients suffe...
Eligibility Criteria
Inclusion
- Inclusion:
- To be eligible to participate in this study, families must have two or more affected pairs of siblings (brothers/sisters) or 3 or more family members affected with intracerebral aneurysms.
- Sporadic aneurysm subjects must have a confirmed aneurysm.
- Exclusion:
- A history of polycystic kidney disease, Marfan's Syndrome, Ehlers Danlos Syndrome, or fibromuscular dysplasia.
Exclusion
Key Trial Info
Start Date :
September 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
5875 Patients enrolled
Trial Details
Trial ID
NCT00071565
Start Date
September 1 2002
End Date
May 1 2015
Last Update
August 18 2015
Active Locations (16)
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1
University of Alabama
Birmingham, Alabama, United States, 35294
2
University of California,
San Francisco, California, United States, 94143-0114
3
University of Florida
Gainesville, Florida, United States, 32610-0265
4
Indianapolis Neurosurgical Group
Indianapolis, Indiana, United States, 46202