Status:
COMPLETED
Family Study of Affective and Anxiety Spectrum Disorders
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Mood Disorders
Sleep Disorders
Eligibility:
All Genders
7-120 years
Brief Summary
This study will examine how depression, anxiety, and migraine run in families. It will help in defining the risk factors for physical, mental, and health problems-as well as define ways that those pro...
Detailed Description
Objective: The chief goal of this study is to identify the endophenotypes of the spectrum of mood disorders using the methods of genetic epidemiology, developmental psychopathology and clinical psych...
Eligibility Criteria
Inclusion
- Since this study is based on systematic recruitment from the local community and other non-clinical settings such as screening protocols from volunteers, there are no specific diagnostic inclusion and exclusion criteria. However, the study targets individuals with mood spectrum conditions and migraine. Criteria for the specific subgroups of mood and anxiety disorders are presented in Table 1. Individuals who do not meet criteria are classified as controls.
- INCLUSION CRITERIA:
- the ability to comprehend the interview, and
- probands must agree to contact at least two relatives (contacting relatives is not required in cases where the participant is enrolled in just the mobile technologies assessments (EMA and Actigraphy).
- EXCLUSION CRITERIA:
- The only exclusion criteria include impaired ability to comprehend the interview or inability to read.
- SPECIFIC INCLUSION AND EXCLUSION CRITERIA BY PROBAND GROUP:
- GENERAL INCLUSION CRITERIA:
- The only inclusion criteria for the study are that the person be English-speaking and ability to read and comprehend the interview.
- BIPOLAR I INCLUSION CRITERIA:
- Lifetime history of DSM-IV Bipolar I or Manic Episode
- BIPOLAR II INCLUSION CRITERIA:
- Lifetime history of DSM-IV Bipolar II with duration of hypomania reduced to 2 or more days (according to RDC)
- MAJOR DEPRESSION INCLUSION CRITERIA:
- Lifetime history of at least 2 episodes of DSM-IV Major Depression
- PANIC/GAD INCLUSION CRITERIA:
- Lifetime history of DSM-IV diagnosis for Panic Disorder or GAD
- PHOBIAS INCLUSION CRITERIA:
- Lifetime history of DSM-IV diagnosis for social anxiety disorder, agoraphobia, or specific phobias (greater than or equal to 3)
- MIGRAINE INCLUSION CRITERIA:
- Lifetime history of IHS migraine with or without Aura
- GENERAL EXCLUSION CRITERIA:
- The only exclusion criteria include impaired ability to comprehend the interview or inability to read.
Exclusion
Key Trial Info
Start Date :
May 21 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
1944 Patients enrolled
Trial Details
Trial ID
NCT00071786
Start Date
May 21 2004
Last Update
December 31 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892