Status:
COMPLETED
MRI in Autosomal Dominant Partial Epilepsy With Auditory Features
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Epilepsies, Partial
Eligibility:
All Genders
21-65 years
Brief Summary
This study will examine the possible structural and functional abnormalities in patients with an inherited form of epilepsy. It will use magnetic resonance imaging (MRI). Uncontrolled epilepsy is a se...
Detailed Description
Objectives: to study potential structural and functional abnormalities in patients with an inherited form of epilepsy. Study Population: Patients with autosomal dominant partial epilepsy with auditor...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients and family members in kindreds with ADPEAF evaluated by Dr. Ruth Ottman at CPMC:
- 14 patients with seizures and the LGl1 mutation.
- 14 family members with the mutation but no seizures.
- 14 Non-affected family members, who are not carriers of the LGl1 mutation.
- 30 normal controls selected at NIH, and screened in the CES outpatient clinic with a physical and neurological examination.
- EXCLUSION CRITERIA:
- Subjects unable or unwilling to undergo MRI, EEG, and MEG.
- Women who are pregnant.
- Subjects under 18.
- Subjects with medical conditions other than ADPEAF that may affect brain function.
- Subjects taking medications or neuroactive substances that may affect brain function.
- Healthy volunteers must be below the age of 55, to reduce the chance of vascular chnages that could affect MRI.
Exclusion
Key Trial Info
Start Date :
November 10 2003
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT00072813
Start Date
November 10 2003
Last Update
July 2 2017
Active Locations (2)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
2
Columbia University
New York, New York, United States, 10032-3784