Status:
COMPLETED
Dobutamine Echocardiography In Patients With Ischemic Heart Failure Evaluated for Revascularization
Lead Sponsor:
Medstar Health Research Institute
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cardiovascular Diseases
Coronary Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To define the role of the assessment of myocardial viability with dobutamine echocardiography (DE) in the clinical evaluation and selection of the best treatment for a high-risk subset of patients wit...
Detailed Description
BACKGROUND: The number of individuals presenting with coronary artery disease (CAD) with impaired left ventricular (LV) function (measured as ejection fraction {EF}\<35%), and clinical evidence of he...
Eligibility Criteria
Inclusion
- Enrollment Requirements
- Symptomatic heart failure defined as NYHA Class II - IV (within 3 months of entry)
- LV less than 35% defined by CMR or gated SPECT studies
- Coronary anatomy suitable for revascularization
Exclusion
- Primary valvular heart disease clearly defined indicating the need for valve repair or replacement
- Patients with concurrent cardiogenic shock or requiring inotropic or intra-aortic balloon support
- PCI planned for CAD treatment
- Acute myocardial infarction within 30 days
- More than one prior cardiac operation
- Non-cardiac illness with life expectancy of less than 3 years
- Non-cardiac illness imposing substantial operative mortality. Patients eligible to enter the study will be further evaluated by the STICH team for SVR eligibility.
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2017
Estimated Enrollment :
319 Patients enrolled
Trial Details
Trial ID
NCT00074724
Start Date
May 1 2003
End Date
April 1 2017
Last Update
April 8 2021
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