Status:
COMPLETED
Technical Development of Strain Rate Echocardiography
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Echocardiography, Doppler
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine heart function using two imaging techniques - echocardiography (ultrasound) and magnetic resonance imaging (MRI) - to evaluate newly developed software for echocardiograph mach...
Detailed Description
The purpose of this protocol is to study the reproducibility of strain rate (SR) echocardiography in normal volunteers and patients with cardiovascular disease. Tissue Doppler ultrasound is a technolo...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Adults older than 18 years will be recruited for the CAD group. Since regional wall motion abnormalities, coronary artery disease, and heart failure are rare in subjects under 21, we will limit this group to adults only.
- Adults older than age 18 who have undergone surgical repair of Tetralogy of Fallot will be recruited. Normal controls will be age-matched to this group of patients.
- Able to provide written informed consent.
- EXCLUSION CRITERIA:
- Patients with pulmonary artery shunts placed within the last 6 months are not eligible to undergo MRI scanning.
- Pregnant or lactating (patients with uncertain pregnancy status will be required to have a screening urine or blood pregnancy test).
- Chronic atrial fibrillation; frequent PVC's (more than 1 every 10 heart beats).
- Cardiac pacemaker, defibrillator, or other metallic implant which would exclude subject from MRI examination (examples: central nervous system aneurysm clips, implanted neural stimulator, cochlear implant, ocular foreign body, insulin pump, metal shrapnel or bullet).
- Inability to provide written informed consent.
- Patients with hemoglobinopathies or renal disease with a creatinine clearance (CrCl) less than 20 ml/min will be excluded from MRI sequences involving administration of MRI contrast agents.
Exclusion
Key Trial Info
Start Date :
January 8 2004
Trial Type :
OBSERVATIONAL
End Date :
October 17 2007
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT00075920
Start Date
January 8 2004
End Date
October 17 2007
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892