Status:
COMPLETED
Acute Renal Failure Trial Network (ATN) Study
Lead Sponsor:
US Department of Veterans Affairs
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Acute Renal Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This is a multi-center, prospective, randomized, parallel-group trial of an intensive strategy vs conventional strategy of renal replacement therapy for the treatment of acute renal failure secondary ...
Detailed Description
Primary Hypothesis: An intensive management strategy for renal support in critically ill patients with acute renal failure decreases mortality as compared to less intensive (conventionally recommended...
Eligibility Criteria
Inclusion
- Acute renal failure clinically consistent with a diagnosis of acute tubular necrosis
- Plan for renal replacement therapy by clinical team
- Receiving care in a critical care unit
- One non-renal organ failure or sepsis
- Age 18 or older
- Patient or surrogate provides informed consent
Exclusion
- Baseline serum creatinine \> 2 mg/dL (177 mol/L) in males, \> 1.5 mg/dL (133 mol/L) in females
- Acute renal failure clinically believed to be due to an etiology other than acute tubular necrosis
- More than 72 hours since meeting both of the following conditions:
- Fulfillment of the definition of ARF; and
- BUN \> 100 mg/dL (36 mmol/L)
- More than 1 hemodialysis treatment or more than 24 hours since starting continuous renal replacement therapy
- Prior kidney transplant
- Pregnancy
- Prisoner
- Weight \> 128.5 kg
- Non-candidacy for renal replacement therapy
- Moribund state
- Patient not expected to survive 28 days because of underlying terminal chronic medical condition
- Comfort-measures-only status
- Participation in a concurrent interventional study
- Patient/surrogate refusal
- Physician refusal
Key Trial Info
Start Date :
October 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2008
Estimated Enrollment :
1124 Patients enrolled
Trial Details
Trial ID
NCT00076219
Start Date
October 1 2003
End Date
July 1 2008
Last Update
August 23 2013
Active Locations (22)
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1
Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock
No. Little Rock, Arkansas, United States, 72114-1706
2
VA Medical Center, San Francisco
San Francisco, California, United States, 94121
3
VA Greater Los Angeles Healthcare System, West LA
West Los Angeles, California, United States, 90073
4
VA Eastern Colorado Health Care System, Denver
Denver, Colorado, United States, 80220