Status:
COMPLETED
Role of the Right Brain in Recovery of Language Function in Chronic Stroke
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Aphasia
Cerebrovascular Accident
Eligibility:
All Genders
Brief Summary
This study will examine in healthy individuals and in patients with aphasia (a language disturbance that is usually caused by stroke, brain disease, or injury) which parts of the brain are involved in...
Detailed Description
Background: Aphasia, a language impairment usually induced by stroke, is typically the result of damage to the left hemisphere. Severity of this disorder can vary across patients, as well as the degre...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- We will include patients with thromboembolic non-hemorrhagic hemispheric lesions and with hemorrhagic hemispheric lesions (as documented by CT or MRI) at least 12 months after the stroke.
- We will choose subjects with chronic stable aphasia, that initially presented with severe aphasia and have partially recovered.
- Assessment of the initial functional state will be taken either from patient report or medical records. All of the aphasic patients are already known to the investigators from the NIDCD.
- EXCLUSION CRITERIA - HEALTHY CONTROLS:
- Unable to perform the task (naming of everyday objects in less than 10 s).
- History of alcohol or drug abuse or psychiatric illness like depression.
- Epilepsy.
- Are less than 18 years of age.
- Pregnant or breast feeding a child.
- EXCLUSION CRITERIA - PATIENTS:
- Unable to perform the task (naming of everyday objects in less than 10 s).
- History of alcohol or drug abuse or psychiatric illness like depression.
- Epilepsy.
- Are less than 18 years of age.
- Pregnant or breast feeding a child.
- Patients with cerebellar or brainstem lesions.
- Patients or subjects with severe uncontrolled medical problems (e.g. cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease).
- Patients or subjects with increased intracranial pressure as evaluated by clinical means.
- Individuals receiving drugs acting primarily on the central nervous system.
Exclusion
Key Trial Info
Start Date :
January 1 2004
Trial Type :
OBSERVATIONAL
End Date :
January 1 2006
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00076479
Start Date
January 1 2004
End Date
January 1 2006
Last Update
March 4 2008
Active Locations (1)
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1
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892