Status:
COMPLETED
Cell Studies of Parkinson's Disease
Lead Sponsor:
National Human Genome Research Institute (NHGRI)
Conditions:
Parkinson Disease
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine and compare blood samples from healthy volunteers and patients with Parkinson's disease to identify abnormalities associated with Parkinson's disease. Disease symptoms include ...
Detailed Description
This study wants to focus on mitochondrial defects associated with Parkinson's disease (PD) and how they relate to alpha-synuclein (SNCA) expression and function. Individuals from families with inheri...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Individuals over the age of 18 from families in which an inherited form of parkinson's disease is apparent will be enrolled. These patients are already enrolled in the Genetic linkage analysis protocol 97-HG-0173.
- The diagnosis of Parkinson's disease must be supported by accepted clinical criteria including: tremor, bradykinesia, rigidity and responsiveness to L-DOPA.
- Unaffected family members found to be at risk, will also be enrolled.
- The normal control group will be comprised of anonymous platelet donors from the NIH Department of Transfusion Medicine and of individuals over the age of 18 with no known neurological disorder and normal neurological examination matched by age and sex that may be actively recruited.
- Individuals with Lewy Body disease (LBD) that meet current criteria for diagnosis (hallucinations, diurnal variation, and dementia associated with extrapyramidal symptoms within a one year period) will also be included in the study.
- EXCLUSION CRITERIA:
- Because some medications can alter mitochondrial function, patients on MAO inhibitors, antidiabetic sulfonylureas and benzodiazepines will be excluded from the study.
- No person under the age of 18 will be enrolled in this study. This is due to the fact that, except for very rare occasions, Parkinson's disease affects only adults.
Exclusion
Key Trial Info
Start Date :
January 14 2004
Trial Type :
OBSERVATIONAL
End Date :
November 30 2006
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00076505
Start Date
January 14 2004
End Date
November 30 2006
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892