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Status:

COMPLETED

MCC-135 as Adjunct Therapy to Primary Percutaneous Coronary Intervention in ST-Segment Elevation Acute Myocardial Infarction Patients

Lead Sponsor:

Tanabe Pharma Corporation

Conditions:

Myocardial Infarction

Eligibility:

All Genders

18+ years

Phase:

PHASE2

Brief Summary

This study is a multicenter, randomized, double-blind, placebo-controlled clinical trial. The primary objectives of this study are to examine the safety, tolerability, and efficacy of intravenous MCC-...

Detailed Description

Patients will be male or female aged 18 years and older who present to the emergency room (ER) \< 6 hours from onset of AMI symptoms. The AMI must be confirmed by a 12-lead electrocardiogram (ECG) and...

Eligibility Criteria

Inclusion

  • Inclusion Criteria
  • Written informed consent must be obtained from the patient (or, in accordance with state and federal laws and IRB regulations, emergency consent procedures may be employed) before enrollment into the study.
  • The patient is a male or female at least 18 years of age.
  • The patient has an estimated weight between 50 kg (110 lbs) and 140 kg (308 lbs).
  • The patient is suspected to have his/her first-documented ST-segment elevation AMI.
  • The patient has symptoms of ischemia of at least 20 minutes continuous duration, the onset of which occurred \< 6 hours prior to study drug infusion. Examples of ischemic symptoms include chest, arm, and/or jaw pain, shortness of breath, nausea, diaphoresis, or other symptoms that the investigator considers to be of ischemic origin.
  • The patient has
  • Anterior MI: \> 2 mm ST elevation in at least two contiguous leads out of V1-V4
  • Inferior MI: \> 2 mm ST elevation in at least two of II, III, and aVF, with \> 10 mm elevation summed for all leads (14, 15)
  • Infero-apical MI: \> 1 mm ST elevation in at least two of II, III, and aVF, with both V5 and V6
  • Infero-lateral MI: \> 1 mm ST elevation in at least two of II, III, and aVF, with both I and aVL
  • Infero-posterior MI: \> 1 mm ST elevation in II, III, and aVF, with \> 1 mm ST depression in at least two leads out of V1-V3
  • The patient is expected to undergo primary PCI within 8 hours from the onset of ischemic symptoms (see Inclusion Criterion #5 above).
  • Women of childbearing potential must have a negative pregnancy test.
  • Exclusion Criteria
  • The patient has a past history of ST-segment elevation MI.
  • The patient has a pathologic arrhythmia or is considered electrically unstable (K+, Ca2+).
  • The patient has thrombolytic therapy planned.
  • The patient is in cardiogenic shock unresponsive to IV fluid.
  • The patient has severe bradycardia with heart rate \<45 beats/minute.
  • The patient has a pre-existing diagnosis of chronic heart failure (NYHA class III-IV).
  • The patient has left bundle branch block.
  • The patient has any cardiomyopathy or pericarditis.
  • The patient has a history of clinically significant bleeding within the last 3 months.
  • The patient has had any type of major trauma, major surgery, or eye, spinal cord, or brain surgery within the last 3 months that, in the opinion of the investigator, would compromise the patient's response to the standard of care.
  • The patient has a history of clinically significant hepatic disturbance.
  • The patient has a history of chronic renal impairment.
  • The patient has had a cerebrovascular accident (CVA) or transient ischemic attack (TIA) within the last 6 months.
  • The patient is a woman who is pregnant or lactating.
  • The patient is currently receiving therapy with catecholamines/sympathomimetics, phosphodiesterase inhibitors, or phosphodiesterase inhibitors with calcium sensitizing activity. Patients will be permitted to enter the study if these drugs were discontinued more than 5 half-lives prior to randomization.
  • The patient has a history of multiple drug allergies (including contrast media).
  • The patient has epilepsy or a history of seizures requiring treatment (this does not include febrile seizures as a child).
  • The patient participated in an investigational drug or device study within the last 3 months.
  • The patient has a current dependence on alcohol or history of other drugs of abuse.
  • The patient has current clinically significant psychiatric or neurologic disease or any other condition that, in the investigator's opinion, would prevent adherence to the requirements of the protocol.
  • The patient is clinically significantly immunocompromised (including, but not limited to AIDS and immune-suppressive therapy \[i.e., chemotherapy, radiation, systemic corticosteroids\]).

Exclusion

    Key Trial Info

    Start Date :

    April 1 2003

    Trial Type :

    INTERVENTIONAL

    End Date :

    August 1 2004

    Estimated Enrollment :

    414 Patients enrolled

    Trial Details

    Trial ID

    NCT00078013

    Start Date

    April 1 2003

    End Date

    August 1 2004

    Last Update

    June 24 2005

    Active Locations (1)

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    Page 1 of 1 (1 locations)

    1

    Massachusetts General Hospital/ Harvard Medical School

    Boston, Massachusetts, United States, 02114