Status:
COMPLETED
Dynamic Light Scattering for Studying Lens Aging and Cataract Formation
Lead Sponsor:
National Eye Institute (NEI)
Conditions:
Cataract
Eligibility:
All Genders
Brief Summary
This study will use dynamic light scattering (DLS) technology to study normal lens aging and early cataract formation. Cataract is a clouding of the lens that interferes with the passage of light to t...
Detailed Description
A new non invasive, in vivo technique to study the molecular changes in the human lens, called Dynamic Light Scattering Device (DLS), has recently been developed. Preliminary studies have shown its po...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients aged 18-80 years will be admitted to this study. There will be no racial or gender bias in the recruitment.
- 227 patients with AREDS nuclear cataract grades 2 or less will be enrolled in the study. 40 patients with AREDS nuclear cataract grade 3 and 4 will also be enrolled.
- For those patients enrolled in the study, both eyes will be evaluated for this protocol. However, the participant has the right to choose to undergo measurements only in one eye. In that case, the eye to be examined will be determined by the partipantt's birth month. If the patient's birth month is an even number, the right eye will be examined; if the patient's birth month is odd, the left eye will be examined.
- EXCLUSION CRITERIA:
- Subjects who have tear film disorders, corneal opacities or disorders, uveitis, glaucoma or who have difficulty fixating, will be excluded.
- Subjects who are thought to be at risk for an adverse reaction to pupil dilation, or have a history of allergic reaction to one of the dilating agents that will be used, will be excluded.
Exclusion
Key Trial Info
Start Date :
April 1 2004
Trial Type :
OBSERVATIONAL
End Date :
April 1 2005
Estimated Enrollment :
267 Patients enrolled
Trial Details
Trial ID
NCT00081991
Start Date
April 1 2004
End Date
April 1 2005
Last Update
March 4 2008
Active Locations (1)
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1
National Eye Institute (NEI)
Bethesda, Maryland, United States, 20892