Status:
COMPLETED
Serotonin Transporters in Obsessive-Compulsive-Related Disorders
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18-65 years
Brief Summary
This study will compare serotonin transporters in patients with obsessive-compulsive disorder (OCD) and healthy volunteers in order to better understand the role of serotonin in OCD. Serotonin is a ch...
Detailed Description
Evidence suggests that the symptoms of obsessive-compulsive disorder (OCD) arise from dysfunction of both the serotonergic and dopaminergic neurotransmitter systems. These two neurotransmitter systems...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients and Controls:
- Age: 18-65.
- Patients- DSM-IV criteria for OCD.
- Controls- not required
- Patients and Controls:
- Good health, with absence of serious medical illnesses, such as congestive heart failure, diabetes, kidney failure, epilepsy or cancer.
- EXCLUSION CRITERIA:
- Healthy Subjects:
- History or current DSM-IV Axis I diagnostic criteria.
- Patients and Controls:
- Current diagnosis of major depressive disorder.
- Patients and Controls:
- Psychotropic medications, including SSRIs and antipsychotic medications. Drug free period must be greater than 4 weeks.
- Patients and Controls:
- Claustrophobia
- Patients and Controls:
- Pregnancy. Women with child bearing potential.
- Patients and Controls:
- Prior participation in other research protocols within the past year such that a radiation exposure together with the present study would exceed the annual limits.
- Patients and Controls:
- Any condition that increases risk for MRI (e.g., pacemaker, metallic foreign body in the eye, etc.)
Exclusion
Key Trial Info
Start Date :
May 10 2004
Trial Type :
OBSERVATIONAL
End Date :
April 9 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00082550
Start Date
May 10 2004
End Date
April 9 2007
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892