Status:
COMPLETED
Genetic and Protein Profiling in Normal and Cancerous Breast Tissue
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Breast Neoplasms
Eligibility:
FEMALE
Brief Summary
This study will collect, analyze, and compare genes and proteins in normal breast tissue with those in various tissues from women with breast cancer to look for changes that are unique to breast cance...
Detailed Description
Background: Defining the molecular profile (gene and protein expression) of normal breast tissue is essential to identifying markers for cellular subtypes in the normal human breast. These markers cou...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Subjects of any age who are undergoing cosmetic breast surgery that entails resection of breast tissue (e.g., reduction mammoplasty) for any reason.
- Women (18 years of age or older) with known or suspected breast cancer who are undergoing a diagnostic biopsy or resection of a primary breast lesions or a site of metastatic tumor.
- Women (18 years of age or older) with breast cancer who are undergoing a pleurocentesis for removal of fluid from a known or suspected malignant pleural effusion.
- All patients or their legal guardians (if the patient is less than 18 years of age) must sign a document of informed consent indicating their understanding that the specimens collected and demographic information provided is only for research purposes. Written assent will be obtained from pediatric patients (less than 18 years of age).
- EXCLUSION CRITERIA:
- 1\. Subjects who are undergoing cosmetic breast procedures such as reduction mammoplasty (collection of normal breast tissue) are excluded if they have a prior history of breast cancer.
Exclusion
Key Trial Info
Start Date :
May 27 2004
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 17 2010
Estimated Enrollment :
216 Patients enrolled
Trial Details
Trial ID
NCT00083733
Start Date
May 27 2004
End Date
November 17 2010
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892