Status:
COMPLETED
Cytokine Gene Polymorphisms in Bone Marrow Failure
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Bone Marrow Diseases
Eligibility:
All Genders
2-80 years
Brief Summary
This study will examine whether cytokine gene polymorphisms affect the progression or response to therapy of bone marrow failure disorders. Cytokine genes instruct cells to produce proteins called cyt...
Detailed Description
The NHLBI Hematology Branch is investigating features that may affect the clinical course of bone marrow failure patients. We are particularly interested in identifying factors, which determine treat...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Participation on a Hematology Branch bone marrow failure treatment protocol.
- Diagnosis with one of the following bone marrow failure conditions:
- Acquired aplastic anemia
- Myelodysplastic syndrome (MDS)
- Pure red cell aplasia (PRCA)
- For adults: Ability to comprehend the investigational nature of the study and provide informed consent. For minors: Written informed consent from one parent or guardian. Informed assent from minors: The process will be explained to the minor on a level of complexity appropriate for their age and ability to comprehend.
- Age greater than or equal to 2 and less than or equal to 80.
- EXCLUSION CRITERIA:
- Subjects unable to comprehend the investigational nature of the laboratory research.
Exclusion
Key Trial Info
Start Date :
February 11 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 14 2007
Estimated Enrollment :
79 Patients enrolled
Trial Details
Trial ID
NCT00085670
Start Date
February 11 2005
End Date
March 14 2007
Last Update
September 10 2020
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892