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Status:

COMPLETED

A Study of ARRY-142886 in Patients With Advanced Cancer

Lead Sponsor:

Array Biopharma, now a wholly owned subsidiary of Pfizer

Conditions:

Advanced Cancer

Eligibility:

All Genders

18+ years

Phase:

PHASE1

Brief Summary

This is a Phase 1 study during which patients with advanced solid tumors will receive investigational study drug ARRY-142886. This study has 2 parts. In the first part, patients will receive increasi...

Eligibility Criteria

Inclusion

  • Key Inclusion Criteria (Part 2):
  • Histopathologically or cytologically confirmed solid tumor that is refractory to standard therapies, or for which no standard therapies exist, or for which the Investigator feels no other active therapy is required for the duration of the study.
  • Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1 or 2.
  • Estimated life expectancy of greater than or equal to 3 months.
  • Patient must have a tumor that is accessible for biopsy and must consent to paired tumor biopsies and normal skin biopsies being taken pre- and post-dose of study drug.
  • Additional criteria exist.
  • Key Exclusion Criteria (Part 2):
  • Uncontrolled or symptomatic brain metastases.
  • Use of investigational drug or device within 30 days prior to first dose of study drug.
  • Major surgery within 30 days prior to study start.
  • Radiotherapy or chemotherapy within 21 days prior to study start (not including palliative radiotherapy at focal sites).
  • Pregnancy or lactation.
  • Known positive serology for the human immunodeficiency virus (HIV), hepatitis B and/or hepatitis C.
  • Additional criteria exist.

Exclusion

    Key Trial Info

    Start Date :

    June 1 2004

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    February 1 2007

    Estimated Enrollment :

    57 Patients enrolled

    Trial Details

    Trial ID

    NCT00085787

    Start Date

    June 1 2004

    End Date

    February 1 2007

    Last Update

    October 14 2020

    Active Locations (3)

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    Page 1 of 1 (3 locations)

    1

    University of Colorado Cancer Center, Anschutz Cancer Center

    Aurora, Colorado, United States, 80010

    2

    Mayo Clinic Rochester

    Rochester, Minnesota, United States, 55905

    3

    Fox Chase Cancer Center

    Philadelphia, Pennsylvania, United States, 19111