Status:
COMPLETED
Biological Markers in Parkinson's Disease
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Parkinson Disease
Eligibility:
All Genders
Brief Summary
This study will identify abnormalities of a protein called alpha synuclein that is found in the brain of patients with Parkinson's disease and related disorders to see if it can serve as a disease mar...
Detailed Description
OBJECTIVE: Parkinson's disease (PD) is a progressive neurodegenerative disorder of unknown etiology in which several underlying pathophysiological mechanisms including proteasomal degradation, mitocho...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA
- Patients between ages 18 to 80 years who are able to give informed consent.
- Before any study related procedure is undertaken, the subject or his representative must sign a consent form.
- In those individuals with dementia, a legal guardian will need to sign the consent form prior to any procedure.
- EXCLUSION CRITERIA
- Medical disorders such as lupus, diabetes, serious heart and kidney disease, thyroid dysfunction and any chronic medical illness with the exception of hypertension and hypercholesterolemia.
- Patients with any history of bleeding diatheses or abnormal platelets or PT/PTT. Patients using anticoagulants and other drugs which can alter PT/PTT.
- Patients with evidence of elevated intracranial pressure based on the imaging studies.
- Pregnant women
- Children
Exclusion
Key Trial Info
Start Date :
July 1 2004
Trial Type :
OBSERVATIONAL
End Date :
June 1 2005
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00088335
Start Date
July 1 2004
End Date
June 1 2005
Last Update
March 4 2008
Active Locations (1)
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1
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892