Status:
COMPLETED
Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Institute on Aging (NIA)
National Center for Research Resources (NCRR)
Conditions:
Alzheimer's Disease
Oxidative Stress
Eligibility:
All Genders
55+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to determine the effect of fish oil and the antioxidant alpha lipoic acid on factors in the blood that are associated with the progression of Alzheimer's Disease (AD).
Detailed Description
Alzheimer's disease (AD) is a serious condition associated with increased inflammation, cholesterol, and oxidative stress (a condition involving an excess of free radicals and a decrease in antioxidan...
Eligibility Criteria
Inclusion
- Diagnosis of probable Alzheimer's Disease or mild cognitive impairment
- Mini Mental State Examination (MMSE) score between 18 and 26
- Clinical Dementia Rating (CDR) of 0.5 or 1.0
- Fluent in English
Exclusion
- Use of lipid lowering medications
- Consumption of fish of more than twice a week
- Use of omega and alpha lipoic acid supplements
- Use of systemic corticosteroids, neuroleptics, anti-Parkinsonian agents, or narcotic analgesics
- Depression
- Any other serious health conditions that may interfere with the study
- Enrollment in another clinical trial
Key Trial Info
Start Date :
April 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2007
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT00090402
Start Date
April 1 2004
End Date
August 1 2007
Last Update
July 21 2017
Active Locations (1)
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1
Oregon Health and Science University
Portland, Oregon, United States, 97239