Status:
COMPLETED
Risk Burden of Lipoprotein Metabolic Gene Haplotypes
Lead Sponsor:
Intermountain Health Care, Inc.
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Atherosclerosis
Cardiovascular Diseases
Eligibility:
All Genders
18+ years
Brief Summary
To investigate the role in coronary heart disease (CHD) of intragenic variation in a network of six genes affecting lipoprotein transport and metabolism.
Detailed Description
BACKGROUND: In recent years, a number of candidate genetic variants (e.g., single nucleotide polymorphisms, SNPs) have been reported to be associated with coronary heart disease (CHD). However, these...
Eligibility Criteria
Inclusion
- Men aged ≤60 years and women ≤70 years. Approximately 3,000 subjects (∼2,000 CAD cases and ∼1,000 angiographically normal controls, matched 2:1 for sex, age, and date of registry entry) were selected. A separate set of cases with highly familial premature CAD (first-degree relative with CHD onset \<55 in men, \<65 in women) from the University of Utah Cardiovascular Genetics Family Tree Registry and a separate set of controls (randomly invited from a public records database) were enrolled as a replication set.
Exclusion
Key Trial Info
Start Date :
August 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2008
Estimated Enrollment :
4303 Patients enrolled
Trial Details
Trial ID
NCT00090441
Start Date
August 1 2004
End Date
July 1 2008
Last Update
January 4 2013
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