Status:
UNKNOWN
Nicotine Treatment of Mild Cognitive Impairment (MCI)
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Age-Related Memory Disorders
Eligibility:
All Genders
55-90 years
Phase:
PHASE1
Brief Summary
The purpose of this 12-month study is to determine whether nicotine, administered in the form of nicotine patches, can improve symptoms of memory loss in some people experiencing mild memory problems ...
Detailed Description
The purpose of this study is to determine whether nicotine can improve symptoms of memory loss in some people experiencing mild memory problems (referred to in this study as "mild cognitive impairment...
Eligibility Criteria
Inclusion
- Specific
- Age 55+.
- Memory complaints and memory difficulties which are verified by an informant.
- Abnormal memory function documented by scoring below the education adjusted cutoff on the Logical Memory II subscale (Delayed Paragraph Recall) from the Wechsler Memory Scale - Revised (the maximum score is 25):
- less than or equal to 8 for 16 or more years of education,
- less than or equal to 4 for 8 - 15 years of education,
- less than or equal to 2 for 0 - 7 years of education.
- Mini-Mental Status Exam score between 24 and 30 (inclusive).
- Clinical Dementia Rating of 0.5 with a memory box score of 0.5 or 1.0.
- General cognition and functional performance sufficiently preserved such that a diagnosis of Alzheimer's disease cannot be made by the site physician at the time of the screening visit.
- No significant cerebrovascular disease: Modified Hachinski score of less than or equal to 4.
- Stable medications for at least 1 month prior to screening.
- Hamilton Depression rating scale score of less than or equal to 12 on the 17-item scale.
- Informant is available who has frequent contact with the participant (e.g. an average of 10 hours per week or more).
- Adequate visual and auditory acuity to allow neuropsychological testing.
- Good general health with no additional diseases expected to interfere with the study.
- Any conditions that subject may have must be stable for 3 months prior to screening.
- Participant is not pregnant, lactating, or of childbearing potential (i.e. women must be two years post-menopausal or surgically sterile).
- Participants will be taking no drugs with pro- or anti-cholinergic properties.
Exclusion
- Any significant neurologic disease such as Alzheimer's disease, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic deficits or known structural brain abnormalities.
- Major depression or another major psychiatric disorder as described in DSM-IV within the past 2 years.
- History of alcohol or substance abuse or dependence within the past 2 years (DSM IV criteria).
- Any significant, unstable medical condition.
- Use of any investigational drugs within 30 days or 5 half-lives, whichever is longer, prior to screening.
- Any tobacco use within the past year.
- Exceptions to these specific Inclusion and Exclusion Criteria (e.g., WMS-R cutoffs) may be made on a case by case basis by the Principal Investigator.
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2008
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00091468
Start Date
September 1 2003
End Date
July 1 2008
Last Update
January 15 2008
Active Locations (3)
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1
Georgetown University Medical Center, Department of Neurology
Washington D.C., District of Columbia, United States, 20057
2
Duke University, Duke Health Center at Morreene Road
Durham, North Carolina, United States, 27705
3
University of Vermont College of Medicine
Burlington, Vermont, United States, 05401