Status:
COMPLETED
Neural Correlates of Observation of Tactile Stimulation in Healthy Subjects
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Healthy
Eligibility:
All Genders
18-75 years
Brief Summary
This study will examine activity in the brain during the observation of touch. Studies with animals have shown that mirror neurons, or nerve cells, are active during the observation and performance of...
Detailed Description
Objective: There is growing evidence that a mirror system for action observation exists. Neurons in the monkey premotor cortex discharge with performance of goal directed actions and also with observ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Only healthy right-handed volunteers aged 18 to 75 years who fulfill the inclusion criteria will be included in this protocol.
- Subjects should be able to sustain attention to the task over 10 minutes.
- All volunteers should have no history of neurological and psychiatric illness.
- EXCLUSION CRITERIA:
- Volunteers with history of severe alcohol or drug abuse, psychiatric illness like severe depression, poor motivational capacity, or severe language disturbances, particularly of receptive nature or with serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 23 or less).
- Volunteers with severe uncontrolled medical problems (e.g. cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age, uncontrolled epilepsy or others).
- Volunteers with increased intracranial pressure (as evaluated by clinical examination).
- Volunteers with unstable cardiac arrhythmia.
- Volunteers with history of hyperthyroidism or individuals receiving drugs acting primarily on the central nervous system.
- Volunteers with more than moderate to severe microangiopathy (as assessed by multiple peri-ventricular T2 hyperintensity on the pre-experimental anatomical MRI), polyneuropathy (as assessed by clinical examination), diabetes mellitus (medical record), or ischemic peripheral disease (as assessed by clinical examination).
- Volunteers who are on medication with the potential to influence nervous system function, who have a history of surgery with metallic implants or a known history of metallic particles in the eye, a cardiac pacemaker, intracardiac lines, neural stimulators, cochlear implants.
- Volunteers who are pregnant.
- Volunteers with significant visual loss/deficits.
- Volunteers with MRI contraindications.
- Volunteers with impaired sensation or neuropathy of the hand.
Exclusion
Key Trial Info
Start Date :
September 3 2004
Trial Type :
OBSERVATIONAL
End Date :
September 2 2008
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00091533
Start Date
September 3 2004
End Date
September 2 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892