Status:
ACTIVE_NOT_RECRUITING
Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Lymphoproliferative Disorder
HHV-8
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will gain information about a rare disorder called KSHV-associated multicentric Castleman s disease (MCD). KSHV, a virus, causes several kinds of cancer, including some forms of MCD. KSHV s...
Detailed Description
Background: * Multicentric Castleman's disease (MCD) is a rare but lethal Kaposi's sarcoma-associated herpesvirus (KSHV) associated lymphoproliferative disorder with a median survival of 2 years. It ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age greater than or equal to 18 years.
- Biopsy proven KSHV-associated MCD, confirmed in the Laboratory of Pathology, CCR.
- Willing to give informed consent.
- EXCLUSION CRITERIA:
- Any abnormality that would be scored as NCI CTC Grade IV toxicity that is unrelated to HIV, its treatment, or to MCD that would preclude protocol treatment and/or observation only.
- Presence of another malignancy requiring current treatment that would preclude the use of all of the study treatments or the ability to monitor the natural history of MCD untreated.
- Pregnant women are excluded from this study as certain of the study agents have the potential for teratogenic effects
- Any condition or set of circumstances that in the opinion of the investigators would make participation in this study unsafe or otherwise inappropriate for a given individual.
Exclusion
Key Trial Info
Start Date :
October 28 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2026
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00092222
Start Date
October 28 2004
End Date
October 1 2026
Last Update
December 31 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892