Status:
COMPLETED
CALERIE (Washington University): Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Aging
Eligibility:
All Genders
50-60 years
Phase:
PHASE1
Brief Summary
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as ...
Detailed Description
Animal studies suggest that caloric restriction (CR), or consuming fewer calories, increases life span, and also protects against some aging-related disease processes such as artherosclerosis and type...
Eligibility Criteria
Inclusion
- Age 50 to 60
- Women must be post-menopausal
- Normal weight to moderately overweight, (Body Mass Index \[BMI\] between 23 - 30)
- In good health, free of major chronic diseases or conditions
- Well motivated
- Reliable
Exclusion
- Major chronic disease or condition that would interfere with exercise or caloric restriction (such as diabetes, coronary artery disease, significant obstructive airway disease, stroke, resting blood pressure over 170 mmHg systolic and/or 100 mmHg diastolic, history or evidence of malignancy, orthopedic or musculoskeletal problems)
- Hormone replacement therapy (DHEA, estrogen, thyroid, testosterone)
- Regular exercise twice or more per week
- Smoking
- Alcoholism
- Frequent travel
Key Trial Info
Start Date :
March 1 2002
Trial Type :
INTERVENTIONAL
End Date :
February 1 2006
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00099138
Start Date
March 1 2002
End Date
February 1 2006
Last Update
December 11 2009
Active Locations (1)
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1
Washington University in St. Louis, School of Medicine
St Louis, Missouri, United States, 63110