Status:
COMPLETED
CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Aging
Cardiovascular Disease
Eligibility:
All Genders
25-50 years
Phase:
NA
Brief Summary
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet improves biomarkers of aging and prevents some age-related chronic diseases such as ...
Detailed Description
This study tests whether chronic caloric restriction improves risk factors of longevity in humans as it is known to do in animals, by measuring a variety of factors dealing with metabolism and oxidati...
Eligibility Criteria
Inclusion
- Resident of greater Baton Rouge area for 1 year or longer
- Men between ages 25-50
- Women between ages 25-45
- Body Mass Index (BMI) between 25-30 (never having had BMI greater than 32)
- Healthy, non-smokers with no history of cardiovascular disease, high blood pressure, diabetes, eating disorder, or major psychiatric disorder
Exclusion
- Pregnant or breastfeeding
- Personal history of cardiovascular disease or elevated high blood pressure (higher than 160/90 mmHg)
- Abnormal electrocardiogram (EKG)
- Personal history of diabetes
- Personal history of major psychiatric disorders
- Personal history of eating disorder
- Smoking
- Exercising regularly (more than twice a week)
- Individuals with alcoholism or other substance abuse
- Post obese (never have had a BMI greater than 32)
- Regular use of medications, except oral contraceptives
- Individuals who were ever injured by a metallic foreign body which was not removed
- Individuals who wear braces on their teeth, have non-removable false teeth, or non-removable bridgework
- Individuals in occupations requiring full alertness and motor skills (airline pilots, etc.) where even a small chance of postural dizziness would be unacceptable.
Key Trial Info
Start Date :
March 1 2002
Trial Type :
INTERVENTIONAL
End Date :
May 1 2006
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00099151
Start Date
March 1 2002
End Date
May 1 2006
Last Update
December 11 2009
Active Locations (1)
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1
Pennington Biomedical Research Center, 6400 Perkins Road
Baton Rouge, Louisiana, United States, 70808