Status:
COMPLETED
Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-85 years
Brief Summary
This study will determine whether magnetic resonance imaging (MRI) can detect damage to certain parts of the brain and analyze the thickness of the brain's outer surface in patients with multiple scle...
Detailed Description
OBJECTIVE: Detection of cortical lesions in patients with multiple sclerosis (MS) using magnetic resonance imaging (MRI) is challenging. Their identification might provide more insight in explaining t...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA - MULTIPLE SCLEROSIS PATIENTS:
- Diagnosis of clinically isolated syndrome or MS.
- Age between 18 and 55.
- EDSS between 0 and 6.5.
- EXCLUSION CRITERIA - MULTIPLE SCLEROSIS PATIENTS:
- Presence of clinical relapse at the time of the enrollment or within the previous 3 months.
- Concomitant systemic disorder or central nervous system diseases of any kind or other related risk factors.
- Previous history of alcohol and substances abuse.
- Medical contraindications for MRI.
- Psychological contraindications for MRI.
- Pregnancy.
- Unable to provide informed consent.
- INCLUSION CRITERIA - HEALTHY VOLUNTEERS:
- Age greater than 18 years.
- EXCLUSION CRITERIA - HEALTHY VOLUNTEERS:
- Systemic disorder or central nervous system diseases of any kind or other related risk factors.
- Previous history of alcohol and substances abuse.
- Medical contraindications for MRI.
- Psychological contraindications for MRI.
- Pregnancy.
- Unable to provide informed consent.
- INCLUSION CRITERIA - STROKE PATIENTS:
- Age greater than 18 years.
- Pure motor hemiparesis secondary to a first and single acute ischemic infarct localized in the white matter of the pyramidal tract (confirmation and location stroke by MRI).
- No other major diseases of the central nervous system or neurological signs.
- No other visible MRI lesions of the corticospinal tract on T2-weighted images (e.g., patients with white matter lesions on tracts not connected with the pyramidal tract and clinically silent will not be excluded).
- EXCLUSION CRITERIA - STROKE PATIENTS:
- Stroke onset less than 3 months prior to the study enrollment.
- Previous history of alcohol and substances abuse.
- Medical contraindications for MRI.
- Contraindications for MRI.
- Critical stenosis of either carotids or vertebrobasilar artery as demonstrated by a Transcranial Doppler.
- Pregnancy.
- Unable to provide informed consent.
Exclusion
Key Trial Info
Start Date :
December 8 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 28 2011
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT00099307
Start Date
December 8 2004
End Date
September 28 2011
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892