Status:
COMPLETED
Study of the Safety of FG-3019 in Incipient Nephropathy Due to Type 1 or Type 2 Diabetes Mellitus
Lead Sponsor:
FibroGen
Conditions:
Diabetes Mellitus
Eligibility:
All Genders
21-80 years
Phase:
PHASE1
Brief Summary
The Phase 1b study is a multi-center trial designed to test the safety, tolerability, biologic activity of escalating doses of FG-3019 in up to 20 patients with type 1 or type 2 diabetes and microalbu...
Eligibility Criteria
Inclusion
- Written informed consent
- Body mass index not exceeding 32.0 kg/m2
- If female, subject must meet one of the following criteria: a) surgically sterile (hysterectomy or bilateral tubal ligation) OR b) at least two years postmenopausal OR c) using a dual method of contraception and have a negative serum pregnancy test if of childbearing potential
- Diagnosis of type 1 or type 2 diabetes according to the American Diabetes Association
- Fasting plasma glucose of ≥ 126 mg/dL or current treatment with oral hypoglycemic agents or insulin
- Microalbuminuria defined as albumin to creatinine ratio in a spot collection (first void) of 30 - 300 mg/gram confirmed by two samples two to three days apart
- Serum creatinine of no more than 1.5 mg/dL for men and no more than 1.1 mg/dL for women
Exclusion
- Female subjects who are pregnant or lactating
- Non-diabetic renal disease
- History of allergic or anaphylactic reaction to human, humanized, chimeric, or murine monoclonal antibodies
- Coronary artery bypass graft surgery, myocardial infarction, cerebrovascular accident, percutaneous transluminal angioplasty, transient ischemic attack, history of unstable angina, known heart failure, uncontrolled cardiac arrhythmia, or uncontrolled hypertension within six months prior to Day 0
- Bilirubin, aspartate aminotransferase (AST), or alanine aminotransferase (ALT) \> 1.5 times the upper limit of normal
- History of cancer of any type in the past 5 years, except non- melanomatous skin cancer, localized bladder cancer, or in situ cervical cancer.
- Clinically significant and uncontrolled medical condition considered a high risk for participation in an investigational study
- Trauma or surgical procedures (including dental) within six months prior to Day 0
- Planned elective surgery during the study and for 3 months following the end of the study
- Participation in studies of investigational drugs within 6 weeks prior to first dose
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00102297
Start Date
January 1 2005
End Date
June 1 2007
Last Update
December 12 2007
Active Locations (5)
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1
UCLA - LA BioMed
Los Angeles, California, United States, 90502
2
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
3
Radiant Research
Dallas, Texas, United States, 75231
4
Diabetes & Glandular Disease
San Antonio, Texas, United States, 78229