Status:
COMPLETED
Brain Function in Focal Dystonia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Dystonia
Eligibility:
All Genders
18+ years
Brief Summary
Objectives The main objectives of this proposal are (1) to characterize motor learning abnormalities in patients with focal dystonia; (2) to show, using transcranial magnetic stimulation, that this a...
Detailed Description
OBJECTIVES: The main objectives of this proposal are (1) to characterize motor learning abnormalities in patients with focal dystonia; (2) to show, using transcranial magnetic stimulation, that this ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy volunteers (aged 18 or older) who are willing to participate.
- Patients (aged 18 and older) with an idiopathic upper limb dystonia, who are able to practice the motor learning task.
- EXCLUSION CRITERIA:
- Subjects with a history of neurological or psychiatric disorder, current use or a history of alcohol or drug abuse, psychiatric disorders requiring hospitalization or prolonged treatment such as substance abuser addiction, head injury with loss of consciousness, epilepsy.
- Subjects with significant hearing loss.
- Subjects receiving drugs acting primarily on the central nervous system.
- Subjects who have been treated with botulinum toxin injections 3 months prior to their participation in the study.
- Subjects who are taking any medication for dystonia at the time of the study.
- Subjects who have already participated in a protocol using a motor learning task.
- Subjects who practice intensively playing any kind of music instrument.
- The following exclusion criteria are due to the use of transcranial magnetic stimulation:
- Subjects with cardiac pacemakers, intracardiac lines, implanted medication pumps.
- Subjects with eye, blood vessel, cochlear, or eye implants.
- Subjects with increased intracranial pressure as evaluated by clinical means.
- Subjects with metal in the cranium.
- Subjects with dental braces (but dental fillings are not a problem), metal fragments from occupational exposure or surgical clips in or near the brain.
- Women in the last trimester of pregnancy will not be studied because they will likely be uncomfortable maintaining a motionless seated posture during the three hour experiment.
Exclusion
Key Trial Info
Start Date :
January 31 2005
Trial Type :
OBSERVATIONAL
End Date :
January 22 2009
Estimated Enrollment :
118 Patients enrolled
Trial Details
Trial ID
NCT00102999
Start Date
January 31 2005
End Date
January 22 2009
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892