Status:
COMPLETED
Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth
Lead Sponsor:
National Institute of Dental and Craniofacial Research (NIDCR)
Conditions:
Gingival Overgrowth
Eligibility:
All Genders
2-80 years
Brief Summary
This study will examine common features of gingival overgrowth (excessive growth of the gums around the teeth) that develops in patients with the hereditary form of the condition and in those who deve...
Detailed Description
The purpose of this protocol is twofold: 1) to continue identification of genes associated with hereditary gingival fibromatosis (HGF), a type of gingival overgrowth 2) to investigate the genes up-reg...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients of any age, gender, and racial/ethnic group with hereditary gingival fibromatosis (HFG) as diagnosed with HGF by clinical appearance that consists of attached gingival covering the lower 1/3 or more of the clinical crowns of teeth in an individual not taking medications associated with gingival changes.
- Blood relatives of affected individuals who are at risk of inheriting HGF.
- Patients of any age, gender, and racial/ethnic group taking one of the three medications associated with drug-induced gingival overgrowth (phenytoin diphenylhydantoin or Dilantin, cyclosporine, or calcium-channel blockers).
- Patients with six or more teeth.
- EXCLUSION CRITERIA:
- Patients with significant cognitive impairment.
- Pregnant patients or lactating patients.
- Patients unwilling to give informed consent.
- Patients with less than six teeth.
Exclusion
Key Trial Info
Start Date :
February 15 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 19 2011
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00104026
Start Date
February 15 2005
End Date
April 19 2011
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892