Status:
COMPLETED
Effect of Transcranial Magnetic Stimulation on Memory
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Healthy
Healthy Volunteer
Eligibility:
All Genders
Brief Summary
This study will examine the effect of transcranial magnetic stimulation (TMS) on short-term memory in healthy adults. Healthy people use their brains to answer short-term memory questions in a differe...
Detailed Description
Psychiatrists have recognized cognitive dysfunction as the principal impediment to recovery and psychosocial rehabilitation of patients with schizophrenia since the first edition of Emil Kraepelin's 1...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- 1\. Male and Female subjects, age 18-55
- EXCLUSION CRITERIA:
- Significant psychiatric, or severe chronic medical illness at the time of the study, or by history. This criterion includes the absence of substance abuse histories, learning disabilities or any other DSM-IV AXIS I or II disorder with documented cognitive impairment. The P.I. or his designate will evaluate medical histories. Medical conditions that are judged not to interfere with the study may be allowed.
- Pregnancy, personal or family history of epilepsy, concurrent use of tricyclic antidepressants, neuroleptic agents, or any licit or illicit drugs that could lower the seizure threshold, or history of complicated migraine.
- Persons with surgically or traumatically implanted ferro-magnetic objects in the head that may pose a physical hazard during magnetic stimulation will also be excluded.
- Use of psychotropic substances in the last 3 months.
- Head injury with a period of more than 15 minutes unconsciousness, or head trauma with any duration loss of consciousness in the last year, or any evidence of functional impairment due to and persisting after head trauma.
- Use of caffeine or tobacco in the 2 hours preceding the test.
- Subjects who have been previously excluded from NIH MRI or TMS protocols for safety reasons.
- Subjects who are found to have eye lesions on exam.
- First degree relative with a history of cognitive disorder with onset before age 55 by subject report, and by collateral report of at least one other family member, if necessary.
Exclusion
Key Trial Info
Start Date :
March 1 2005
Trial Type :
OBSERVATIONAL
End Date :
February 1 2006
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00105118
Start Date
March 1 2005
End Date
February 1 2006
Last Update
March 4 2008
Active Locations (1)
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1
National Institute of Mental Health (NIMH)
Bethesda, Maryland, United States, 20892