Status:
RECRUITING
MRS Measurement of Glutamate and GABA Metabolism in Brain
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Normal Physiology
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of \[13\]C as it is naturally metabolized from glucose to specific chemical transmitters. From this metho...
Detailed Description
13C is a stable (i.e., non-radioactive) isotope of carbon with a natural abundance of \~1%. Following infusion of \[13C\]glucose and/or \[13C\]acetate, in vivo MRS (magnetic resonance spectroscopy) ca...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- 18-65 years of age
- Able to give written informed consent
- Healthy based on medical history and physical exam
- Enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
- EXCLUSION CRITERIA:
- Any current Axis 1 diagnosis
- Clinically significant laboratory abnormalities
- Positive HIV test
- Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
- History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
- Prescription psychotropic medication; drug free less than 8 weeks (anticholinergics, benzodiazepine, fluoxetine, antipsychotics, and anticonvulsants)
- Serious medical illness as determined from H\&P or laboratory testing including Diabetes
- Inability to lie flat on camera bed for about two and a half hours
- Pregnant or breastfeeding
- Current substance use disorder based on DSM-5
- NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.
Exclusion
Key Trial Info
Start Date :
September 6 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 11 2030
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00109174
Start Date
September 6 2006
End Date
March 11 2030
Last Update
January 8 2026
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892