Status:
COMPLETED
Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial
Lead Sponsor:
Kumamoto University
Conditions:
Coronary Disease
Arteriosclerosis
Eligibility:
All Genders
30-85 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine the effects of low-dose aspirin for the primary prevention of vascular events in patients with type 2 diabetes in Japan.
Detailed Description
There is a worldwide epidemic of diabetes and the number of individuals with diabetes is set to increase further. As individuals with diabetes are at high risk of accelerated atherosclerosis and throm...
Eligibility Criteria
Inclusion
- Patients have type 2 diabetes mellitus (30 or more years old and 85 years old or less).
- Patients give their informed consent to participate.
Exclusion
- Patient has electrocardiographic changes, including ischemic ST-segment depression, ST-segment elevation, or pathologic Q waves.
- Patient has fixed ischemic heart disease, utilizing coronary angiography.
- Patient has cerebral vascular disease, including cerebral infarction, past hemorrhage, and experience of transient ischemic attack.
- Patient has arteriosclerotic disease, which needs internal medicine and/or surgical medical treatment.
- Patient has already taken the following anti-platelet or anti-thrombotic medicine: aspirin, ticlopidine, cilostazol, dipyridamole, trapidil, warfarin, and argatroban.
- Patient has severe gastric and/or duodenal ulcer.
- Patient has severe liver dysfunction.
- Patient has severe renal dysfunction.
- Patient has allergy for aspirin.
- Patient has atrial fibrillation.
- Pregnancy or the possible case of pregnancy.
Key Trial Info
Start Date :
December 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
2539 Patients enrolled
Trial Details
Trial ID
NCT00110448
Start Date
December 1 2002
End Date
April 1 2008
Last Update
November 2 2016
Active Locations (2)
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1
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Kumamoto, Kumamoto, Japan, 860-8556
2
First Department of Internal Medicine, Nara Medical University
Kashihara, Nara, Japan, 634-8522