Status:
COMPLETED
Oral Vitamin B12 Supplementation and Cognitive Performance in Elderly People
Lead Sponsor:
Wageningen University
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
Cognitive Decline
Cognitive Symptoms
Eligibility:
All Genders
70+ years
Phase:
NA
Brief Summary
The purpose of this trial is to study the effects of oral vitamin B12 supplementation and vitamin B12 combined with folic acid supplementation on cognitive performance for 24 weeks in elderly people w...
Detailed Description
Mild vitamin B12 deficiency is highly prevalent in old age. Reasons for this high prevalence are not fully understood, but include atrophic gastritis and bacterial overgrowth which affect the absorpti...
Eligibility Criteria
Inclusion
- Mild vitamin B12 deficiency:
- Low plasma vitamin B12 concentration (100 \< B12 \< 300 pmol/L)
- Elevated methylmalonic acid (MMA) concentration (\> 0.32 umol/L)
- Creatinine concentration \< 120 umol/L
Exclusion
- Severe cognitive impairment
- Anemia
- Gastrointestinal surgery or diseases
- Use of vitamin B12 injections or supplements containing \> 25 ug vitamin B12 and/or 200 ug folic acid
- \< 90% compliance during a 2 week placebo run in period
- No written informed consent
- Participation in other research studies
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
End Date :
January 1 2005
Estimated Enrollment :
165 Patients enrolled
Trial Details
Trial ID
NCT00111267
Start Date
May 1 2003
End Date
January 1 2005
Last Update
June 24 2005
Active Locations (1)
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1
Wageningen University
Wageningen, Gelderland, Netherlands, 6700 EV