Status:
COMPLETED
Mechanisms of Skin Repair by Topical Estrogen
Lead Sponsor:
University of Michigan
Conditions:
Skin Wrinkling
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the way by which estrogen improves the appearance of sun damaged human skin. Accumulating evidence suggests that estrogen, taken by post menopausal women, m...
Detailed Description
The objectives of the study are to determine if topically-applied 17-beta estradiol (E2), alone or in combination with clobetasol, will produce histological and molecular effects distinguishable from ...
Eligibility Criteria
Inclusion
- Healthy post-menopausal (without spontaneous menstrual bleeding for at least 1 year) women, and men, at least 50 years of age and any racial/ethnic type.
- Subjects must understand and sign the informed consent prior to participation.
- Subjects must be in generally good health.
- Subjects must be available for follow-up visits to comply with the requirements of the protocol.
- Not on estrogen replacement therapy within the past 3 months.
- No nonsteroidal anti-inflammatory drugs two weeks prior to study entry.
- No topical steroids two weeks prior to study entry.
- You must live within a reasonable driving distance of Ann Arbor, Michigan, and/or be able to attend all of the scheduled appointments during the study.
Exclusion
- History of keloid formation or hypertrophic scarring.
- History of reaction to lidocaine anesthetic.
- Subjects with significant medical history or concurrent condition which the investigator(s) feel is not safe for study participation and which would impair evaluation of test sites.
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
152 Patients enrolled
Trial Details
Trial ID
NCT00113100
Start Date
August 1 2004
End Date
June 1 2007
Last Update
May 21 2015
Active Locations (1)
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1
University of Michigan Department of Dermatology
Ann Arbor, Michigan, United States, 48109