Status:
COMPLETED
Rosuvastatin Affecting Aortic Valve Endothelium
Lead Sponsor:
Hospital Pedro Hispano
Collaborating Sponsors:
Northwestern University
Conditions:
Atherosclerosis
Hypercholesterolemia
Eligibility:
All Genders
50+ years
Brief Summary
Recent studies support the hypothesis that aortic stenosis (AS) develops due to atherosclerosis affecting the aortic valve endothelium. The study's aim was to assess Rosuvastatin on the hemodynamic pr...
Detailed Description
Background: Recent retrospective studies support the hypothesis that statins slow the progression of aortic stenosis. The aim of this study was to assess the effect of Rosuvastatin on hemodynamic prog...
Eligibility Criteria
Inclusion
- Asymptomatic AS
- Normal ejection fraction
- Elevated LDL \>130 mg/dl
Exclusion
- Echocardiographic evidence of rheumatic mitral valve disease,
- Previous statin therapy,
- Congenital heart disease (bicuspid aortic valve),
- Subaortic obstruction,
- Creatinine ≥ 2,0 mg/dl (to avoid the potential confounder of an elevated serum \[CaP04\]),
- Evidence of liver disease,
- Greater than mild aortic regurgitation and previous aortic valve surgery
Key Trial Info
Start Date :
September 1 2003
Trial Type :
OBSERVATIONAL
End Date :
May 1 2005
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00114491
Start Date
September 1 2003
End Date
May 1 2005
Last Update
October 31 2006
Active Locations (1)
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1
Hospital Pedro Hispano
Porto, Portugal