Status:
COMPLETED
Serotonin Effect in Functional Dyspepsia
Lead Sponsor:
Radboud University Medical Center
Conditions:
Dyspepsia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to investigate whether Efexor (venlafaxine) is effective in the treatment of functional dyspepsia.
Detailed Description
BACKGROUND: A good 60% of patients presenting with upper abdominal complaints have functional dyspepsia. Usually, acid-suppressive drugs are given as first-line therapy for upper gastrointestinal symp...
Eligibility Criteria
Inclusion
- Persistent upper gastrointestinal symptoms;
- Absence of any serious organic cause of the complaints at previous upper gastrointestinal endoscopy (including gastric ulcer, carcinoma, oesophageal reflux disease, portal hypertension, hernia hiatus \>2 cm or severe gastritis);
- Over 18 years of age;
- Written informed consent.
Exclusion
- History of bipolar disorder;
- Contra-indication for venlafaxine;
- Current or planned pregnancy or lactation;
- Diagnosed alcoholism, anorexia nervosa or bulimia;
- Current or recent (within the last two weeks) use of a selective serotonin re-uptake inhibitor (SSRI) or MAO-inhibitor;
- Any other condition or circumstance that, in the opinion of the investigator or the physician, would compromise the subject's successful participation in this trial.
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2007
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00115362
Start Date
July 1 2005
End Date
July 1 2007
Last Update
September 24 2007
Active Locations (6)
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1
Radboud University Nijmegen Medical Center
Nijmegen, P.O. Box 9101, Netherlands, 6500 HB
2
Rijnstate Hospital
Arnhem, Netherlands
3
Slingeland Hospital
Doetinchem, Netherlands
4
Gelderse Vallei Hospital
Ede, Netherlands