Status:
COMPLETED
Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure
Lead Sponsor:
University of Calgary
Collaborating Sponsors:
The Centre for the Advancement of Health
Conditions:
Hypertension
Hypotension
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether continuing or discontinuing furosemide (a diuretic) on the day of elective noncardiac surgery for those who take furosemide on a chronic basis, causes...
Detailed Description
A significant proportion of patients who undergo surgery take medications on a chronic basis. Little is known about the effects of these medications on the successful conduct of anesthesia and surgery...
Eligibility Criteria
Inclusion
- All adults referred to preoperative assessment clinics by surgeons for elective non-cardiac surgery who routinely take furosemide.
- Participants must also be able to give informed consent
Exclusion
- Less than 18 years of age
- Have comorbid conditions with which brief periods of hypotension may be particularly harmful such as: 1) pregnancy; 2) baseline hypotension (systolic \<100 mmHg at the preoperative assessment clinic); 3) autonomic dysfunction; 4) severe aortic stenosis.
- Patients who take furosemide only on an 'as needed basis' rather than 'regularly'.
- Those patients who take less than 10 mg of furosemide daily
- Those patients who are undergoing local anesthetic only surgical procedures
- Patients who are unwilling or unable to give informed consent.
Key Trial Info
Start Date :
September 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2007
Estimated Enrollment :
198 Patients enrolled
Trial Details
Trial ID
NCT00115726
Start Date
September 1 2000
End Date
April 1 2007
Last Update
February 22 2008
Active Locations (3)
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1
The Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
2
Foothills Hospital
Calgary, Alberta, Canada, T6R 1R4
3
University of Western Ontario
London, Ontario, Canada, N6A 5C1