Status:
UNKNOWN
Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood
Lead Sponsor:
Groningen Research Institute for Asthma and COPD
Conditions:
Asthma
Healthy
Eligibility:
All Genders
18-50 years
Brief Summary
The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased adenosine r...
Eligibility Criteria
Inclusion
- Asthmatic Subjects -
- Clinical diagnosis of asthma
- Steroid naive or subjects not using their inhaled steroids for the last 4 weeks, short-acting beta-agonist for rescue medication
- FEV1 \> 70% of predicted
- Positive skin prick test for house dust mite, cat or grass pollen
- PC20 methacholine or histamine \< 8 mg/ml
- Asthmatic Subjects -
Exclusion
- Use of systemic steroids in the previous 6 weeks
- Asthma exacerbations in the previous 6 weeks
- Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago
- Healthy Subjects - Inclusion Criteria:
- No airway complaints
- FEV1 \> 90% of predicted
- Negative skin prick test
- PC20 methacholine or histamine \> 8 mg/ml
- Healthy Subjects -
Key Trial Info
Start Date :
July 1 2005
Trial Type :
OBSERVATIONAL
End Date :
February 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00116311
Start Date
July 1 2005
End Date
February 1 2007
Last Update
March 21 2007
Active Locations (1)
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1
University Medical Center Groningen, Department of Pulmonology
Groningen, Netherlands, 9713 GZ