Status:
COMPLETED
Shingles: Immune Effects of Tai Chi
Lead Sponsor:
National Institute on Aging (NIA)
Collaborating Sponsors:
National Center for Complementary and Integrative Health (NCCIH)
Conditions:
Aging
Herpes Zoster
Eligibility:
All Genders
60-90 years
Phase:
PHASE2
Brief Summary
The purpose of this trial is to evaluate the effects of Tai Chi Chih versus Health Education on shingles immunity in older adults as measured by unstimulated and vaccine-stimulated responses. The seco...
Detailed Description
Shingles, also known as herpes zoster (HZ), is more common in older persons due to the weakening of the immune system with advancing age. Psychosocial stresses in the older adult also correlate with t...
Eligibility Criteria
Inclusion
- Older than 60 years of age at time of entry
- History of varicella or long term (\>30 years) residence in the continental USA
- Accessible geographically
Exclusion
- Immunosuppression resulting from neoplastic disease, corticosteroids or other therapy
- Significant underlying illness that would be expected to prevent completion of the study; any other condition (e.g. extensive psoriasis, chronic pain syndrome, cognitive impairment, severe hearing loss) that in the opinion of the investigator might interfere with the required evaluations
- Not ambulatory (bed-ridden)
- Prior HZ or prior receipt of varicella vaccine
- Allergic sensitivity to neomycin
- Receipt of immune globulin or other blood product within 3 months before the study period
- Receipt of other immunizations (e.g., hepatitis B vaccine) within 1 month of immunization
- Women who are not post-menopausal
- Acutely depressed or a suicidal risk
- Unable to commit to intervention schedule
- No history of varicella or varicella vaccination or no evidence of VZV immunity
- Contact with immunosuppressed individuals or pregnant women who do not have a history of chickenpox
- Active infections such as tuberculosis
Key Trial Info
Start Date :
July 1 2001
Trial Type :
INTERVENTIONAL
End Date :
December 1 2004
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT00118885
Start Date
July 1 2001
End Date
December 1 2004
Last Update
December 11 2009
Active Locations (1)
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1
Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute
Los Angeles, California, United States, 90095