Status:
COMPLETED
Study of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection
Lead Sponsor:
Baylor College of Medicine
Collaborating Sponsors:
Bill and Melinda Gates Foundation
Conditions:
Hookworm Infection
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
The primary objective of this clinical trial is to determine the safety and tolerability of the Na-ASP-2 Hookworm Vaccine in healthy subjects following the administration of 3 intramuscular (IM) injec...
Detailed Description
There is an urgent need for new tools to control human hookworm infection and to reduce its burden of disease in developing countries. This is especially true for children and women of reproductive ag...
Eligibility Criteria
Inclusion
- Healthy adults 18 to 45 years of age.
- Signed informed consent.
- History, physical exam, and laboratory tests indicating good general health obtained prior to the first injection.
- All females must have a negative pregnancy test (FDA-approved test for β human chorionic gonadotropin \[β-HCG\]) on the day of the first injection.
- Serologic tests for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), and hepatitis C virus (HCV) are negative at screening.
- All subjects must agree to use an acceptable method of birth control from the start of screening until 2 weeks after the third injection. Acceptable methods for female subjects include hormonal contraceptives, intrauterine device (IUD), diaphragm with spermicide, condoms, abstinence, surgically sterile (hysterectomy), and surgically sterile partner. Acceptable methods for male subjects include surgical sterilization, condoms, partner who uses an acceptable method of birth control, and abstinence.
Exclusion
- Any history of anaphylaxis or allergy to vaccine components or allergy to insect stings, including bee stings.
- A past or current history of hookworm infection.
- BMI \< 18.0 or \> 30.0.
- Recent (\< 72 hours) history of febrile illness at the time of vaccination (temperature \> 99.6°F or equivalent).
- Received any immune globulin or blood product 3 months prior to injection or scheduled within 4 weeks thereafter.
- Had vaccination with a live virus vaccine within 4 weeks before receipt of the vaccine or scheduled within 4 weeks thereafter.
- Had vaccination with a killed vaccine, or allergy treatment with antigen injections within 14 days of initial study injection.
- Received an investigational agent within 4 weeks of initial study injection.
- Known or suspected impairment of immunologic function including, but not limited to clinically significant liver disease, diabetes mellitus, moderate to severe kidney impairment (creatinine \> 1.5), any history of malignancy (except squamous cell or basal cell skin cancer), HIV infection or autoimmune diseases, or concomitant immunosuppressive medication such as glucocorticosteroids.
- A history of essential hypertension, gastrointestinal abnormalities such as peptic ulcer disease, cardiac (ECG abnormalities), pulmonary, hepatic, renal, pancreatic, or neurologic disease.
- Taken prescription medications with the exception of subjects on a stable regimen (\> 30 days) of: (1) hormone replacement therapy, (2) use of nasal steroids, (3) topical therapy, (4) certain classes of antidepressants (i.e., selective serotonin re-uptake inhibitors), (5) oral contraceptives, (6) nonsteroidal anti-inflammatory agents, or (7) antihistamines or decongestants for seasonal allergies taken as needed.
- Contraindication to IM injection such as anti-coagulant therapy or thrombocytopenia.
- Pregnant, nursing, or expecting to conceive during the study.
- Any history of chronic alcohol or drug abuse or current treatment with any known prescribed or over-the-counter supplements that may be hepatotoxins.
- Any subject who, in the Investigator's opinion, will be unable to adhere to protocol requirements.
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2006
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00120081
Start Date
April 1 2005
End Date
September 1 2006
Last Update
May 31 2017
Active Locations (1)
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1
George Washington University Medical Center
Washington D.C., District of Columbia, United States, 20037