Status:
WITHDRAWN
Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones
Lead Sponsor:
Children's Mercy Hospital Kansas City
Conditions:
Kidney Calculi
Eligibility:
All Genders
5-17 years
Phase:
NA
Brief Summary
High amounts of calcium in the urine (hypercalciuria) can cause development of kidney stones in children. Treatment for these children includes plenty of fluids, a low-salt diet and medications such a...
Detailed Description
Hypercalciuria is a common clinical pediatric problem that in some children is associated with renal stones. Most renal stones (80%) are formed by calcium oxalate, calcium phosphate phases (apatite), ...
Eligibility Criteria
Inclusion
- Children aged 5-17 years with idiopathic hypercalciuria who have history of kidney stones.
- Healthy children aged 5-17 years without a history of hypercalciuria or kidney stones.
Exclusion
- Children with urolithiasis secondary to metabolic disorders unrelated to hypercalciuria (e.g. oxaluria, hypocitraturia, cystinuria), or due to secondary causes of calciuria (hypercalcemia, hyperparathyroidism, corticosteroids, furosemide).
- Children with renal insufficiency, active urinary tract infection, hyperkalemia, gastrointestinal diseases, heart failure.
- Children who receive angiotensin-converting enzyme inhibitors, anticholinergic medications or digitalis.
- Children who cannot safely stop receiving the prohibited concomitant medications due to other underlying medical conditions
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00120731
Start Date
July 1 2005
End Date
May 1 2007
Last Update
November 5 2020
Active Locations (1)
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1
The Children's Mercy Hospital
Kansas City, Missouri, United States, 64108